A genomic catalog of Earth’s microbiomes
Publication Year
2021
Type
Journal Article
Abstract
The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth’s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes. © 2020, The Author(s).
Keywords
Agricultural robots,
Ecology,
Genes,
metabolism,
Metabolites,
Viruses,
Agricultural soils,
Comparative analysis,
Engineered environments,
Interactive exploration,
Metabolic modeling,
Operational taxonomic units,
Phylogenetic diversity,
Secondary metabolites,
Bacteria,
archaeon,
Article,
habitat,
human,
metagenome,
microbiome,
microorganism,
nonhuman,
sea,
soil,
virus,
animal,
bacterium,
classification,
ecosystem,
genetics,
isolation and purification,
metabolomics,
metagenome,
metagenomics,
microbiology,
phylogeny,
procedures,
publication,
Air Microbiology,
Animals,
Archaea,
Bacteria,
Catalogs as Topic,
Ecosystem,
Humans,
Metabolomics,
metagenome,
metagenomics,
phylogeny,
Soil Microbiology,
Viruses,
Water Microbiology
Journal
Nature Biotechnology
Volume
39
Pages
499-509